Nauck MA, Quast DR, Wefers J, Pfeiffer AFH (2021) The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update
Physical function improved significantly across all measures
GLP-1 medications include tirzepatide (Mounjaro, Zepbound), liraglutide (Saxenda, Victoza), dulaglutide (Trulicity), and exenatide (Byetta, Bydureon BCise)
However, findings from the Phase II ATLAS trial, presented at the recent Digital International Liver Congress, showed that some combinations did lead to significant improvements in fibrosis and other measures of liver health
32 As previously explained, the mediator Akt is also demonstrated to activate mTOR, allowing beta cell growth through cell cycle progression and by enhancing protein synthesis